AB-Free Kava and its Kavalactones Suppress Cigarette Smoke- and Lipopolysaccharide-Induced Lung Inflammation: Efficacy and Mechanisms
Gujie Xu, Tengfei Bian, Breanne Freeman, Yifan Wang, Allison M. Lynch, Chandra Kumar Maharjan, Tyler H. Montweigomery, Leah R. Reznikov, Adriaan W. Bruijnzeel, Weizhou Zhang, Chengguo Xing
This study identifies bioactive kavalactones in AB-free kava that suppress lung inflammation via PKA/CREB/COX-2 signaling, offering a new therapeutic approach for smoke-induced pulmonary diseases.
bioRxiv · Aug 25, 2026 · PreprintImmunology