Chandra Kumar Maharjan

This study identifies bioactive kavalactones in AB-free kava that suppress lung inflammation via PKA/CREB/COX-2 signaling, offering a new therapeutic approach for smoke-induced pulmonary diseases.

This paper identifies IKKβ and NR4A1 as drivers of AML and develops a PROTAC to degrade them, showing potent cytotoxicity and reduced leukemia progression in mice.

This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.

The paper identifies epithelial IL-2 as critical for maintaining NK cell function in mammary glands, leading to improved immunosurveillance and prevention of tumor development.