Weizhou Zhang

AB-Free Kava and its Kavalactones Suppress Cigarette Smoke- and Lipopolysaccharide-Induced Lung Inflammation: Efficacy and Mechanisms

This study identifies bioactive kavalactones in AB-free kava that suppress lung inflammation via PKA/CREB/COX-2 signaling, offering a new therapeutic approach for smoke-induced pulmonary diseases.

PROTAC-Mediated Targeting of IKKβ and NR4A1 for AML Therapy

This paper identifies IKKβ and NR4A1 as drivers of AML and develops a PROTAC to degrade them, showing potent cytotoxicity and reduced leukemia progression in mice.

CerS2 is a druggable target in triple-negative breast cancer

This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

This study uses scRNA-seq to identify novel immune subsets and checkpoint programs in healthy dogs, revealing functional roles of immune regulators.

Proteolysis targeting chimera extracellular vesicles for therapeutic development treating triple negative breast cancer

This paper demonstrates that microfluidic droplet-based electroporation (microDES) enhances PROTAC drug delivery via extracellular vesicles, improving therapeutic efficacy and safety in a TNBC mouse model.

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

FICTURE: Scalable segmentation-free analysis of submicron resolution spatial transcriptomics

FICTURE provides a scalable segmentation-free method for analyzing high-resolution spatial transcriptomics data, revealing detailed tissue architecture in complex regions.

Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands

The paper identifies epithelial IL-2 as critical for maintaining NK cell function in mammary glands, leading to improved immunosurveillance and prevention of tumor development.

AP-2γ is Required for Maintenance of Pluripotent Mammary Stem Cells

This study shows that AP-2γ is essential for maintaining pluripotent mammary stem cells and their ability to form mammary gland structures.