Enhanced DNA Scanning and Target Specificity via Motif Sequestration
Jonathan S. Montgomery, Ehsan Akbari, Alexandar L. Hansen, Aparna Unnikrishnan, Michael Guy Poirier, Mark P. Foster
This study shows how the Cre recombinase uses a sequestered conformation to enhance DNA scanning efficiency and target specificity by modulating its binding affinity and diffusion behavior.
bioRxiv · Oct 18, 2026 · PreprintBiophysics