Mark P. Foster

This study shows how the Cre recombinase uses a sequestered conformation to enhance DNA scanning efficiency and target specificity by modulating its binding affinity and diffusion behavior.

The paper investigates how Cre recognizes loxP sites through noncontacted DNA positions, showing that these positions influence binding and conformational changes.

The paper uses native mass spectrometry to study ATP binding to Rho, revealing binding to hexameric and lower-order complexes and super-stoichiometric binding at partially formed sites.

This paper investigates how protein and DNA conformational changes contribute to the specificity of Cre recombinase in binding and recombining loxP sequences.

The paper investigates the conformational dynamics of Loz1's C2H2 zinc fingers in S. pombe, revealing how zinc binding and dynamic behavior regulate gene repression.

The paper shows that CIB2/3 and TMC1/2 form complexes essential for hair-cell mechanotransduction in vertebrates, supported by structural and functional analyses.

This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.

This study uses NMR techniques to investigate the structural and dynamic changes in TRAP upon Trp binding, revealing a mechanism for cooperative ligand binding.