Jonathan S. Montgomery

This study shows how the Cre recombinase uses a sequestered conformation to enhance DNA scanning efficiency and target specificity by modulating its binding affinity and diffusion behavior.

The paper investigates how Cre recognizes loxP sites through noncontacted DNA positions, showing that these positions influence binding and conformational changes.

This paper investigates how protein and DNA conformational changes contribute to the specificity of Cre recombinase in binding and recombining loxP sequences.

The paper shows that CIB2/3 and TMC1/2 form complexes essential for hair-cell mechanotransduction in vertebrates, supported by structural and functional analyses.

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.