Author

Aparna Unnikrishnan

The Ohio State UniversityORCID 0000-0002-6668-8659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alexandar L. HanseniD· 1 shared Aye C. ThwiniD· 1 shared Charles S. CraikiD· 1 shared Cory M. NadeliD· 1 shared Daniel R. SouthworthiD· 1 shared Dong hee ChungiD· 1 shared Ehsan AkbariiD· 1 shared Emily J. ConnellyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Alexandar L. HansenORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 18, 2026

Enhanced DNA Scanning and Target Specificity via Motif Sequestration

Jonathan S. Montgomery, Ehsan Akbari, Alexandar L. Hansen…·Mark P. Foster

This study shows how the Cre recombinase uses a sequestered conformation to enhance DNA scanning efficiency and target specificity by modulating its binding affinity and diffusion behavior.

DOI 10.64898/2026.10.12.758470

experimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 15, 2025

Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions

Aparna Unnikrishnan, Dong hee Chung, Emily J. Connelly…·Daniel R. Southworth

This study determines the structures of CHIP stabilized by Fab antibodies, revealing conformational switches that regulate its E3 ligase and chaperone functions.

1 citation

cryo-EMexperimental assay

𝕏 PostBluesky