Immunotoxicology and immune responses

Ovarian hormone deficiency enhances wood smoke-induced immune dysfunction via transcriptomic and metabolic alterations

This study shows ovarian hormone deficiency increases vulnerability to wood smoke-induced immune disruption in bone marrow by altering transcriptional and metabolic programs in macrophages.

Divergent Immediate and Delayed Effects of Juvenile Exposure to Doxorubicin on the Thymus in C57BL/6 Mice

This study examines the immediate and delayed effects of juvenile doxorubicin exposure on thymic immune cell populations and gene expression in mice, revealing thymic atrophy and immunosenescence.

Title: 4-week GLP immunotoxicity assessment of lactoferrin alpha produced by Komagataella phaffii in Sprague Dawley rats

This study assesses the 4-week immunotoxicity and toxicokinetics of lactoferrin alpha produced by Komagataella phaffii in rats, finding no toxicologically significant changes at high doses.

Toxicogenomic Assessment of In Vitro Macrophages Exposed to Profibrotic Challenge.

This study uses RNA sequencing to analyze immune gene responses in macrophages exposed to bleomycin, identifying dose-dependent gene alterations and linking them to cytokine and proteinase activity.

Single-cell RNA Sequencing Reveals Methamphetamine Inhibits the Liver Immune Response with Involvement of the Dopamine D1 Receptor

This study uses single-cell RNA sequencing to show that chronic methamphetamine exposure alters liver immune cell composition and function, with involvement of the dopamine D1 receptor.