Davis M. Seelig

This study identifies cell surface proteome changes in MPNSTs due to PRC2 loss, revealing PTK7 as a promising therapeutic target using antibody-drug conjugates.

This paper develops a vitrification method to preserve precision-cut liver slices (PCLS) for 3 days, showing high viability and function compared to conventional cryopreservation.

This study examines the immediate and delayed effects of juvenile doxorubicin exposure on thymic immune cell populations and gene expression in mice, revealing thymic atrophy and immunosenescence.

This study shows fisetin extends lifespan and reduces senescent cells in a mouse model of RDEB.

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

This paper develops and validates a 3D genomic blood test for diagnosing multiple canine cancers with high sensitivity and specificity.

This study develops human iPSC-derived tumor models to investigate the cooperative effects of H3.3K27M and PDGFRA mutations in DMG, identifying therapeutic vulnerabilities.

This study uses RT-QuIC to detect CWD prion seeding activity in skeletal muscles of infected white-tailed deer, finding prions in consumption-relevant tissues and highlighting their broader distribution.

This study shows that VEGF signaling is activated by UV exposure and that inhibiting it can prevent sunburn symptoms in mice, suggesting a new therapeutic approach for UV-induced skin damage.