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The paper identifies 545 expression-modulating variants in CD4+ T cells linked to autoimmune diseases and shows they regulate genes in a lymphocyte activation network.

This study uses genome and transcriptome data from apple species to show how selection and gene flow shaped the cultivated apple genome, revealing distinct gene pools and adaptive introgression patterns.

This study identifies CHS2 gene knockout as a mechanism conferring high resistance to Vip3Aa in Spodoptera exigua and Agrotis ipsilon.

This study reconstructs the evolutionary history of ancient Salmonella enterica using 53 new genomes, revealing host adaptation events and convergent evolution in pathogenic lineages.

The paper develops an RNAi yeast bait that targets the Shaker gene in SWD, causing high mortality without affecting other dipterans.

This study shows that perinatal lead exposure increases mouse embryonic weight and alters gene expression in neuronal and sexually dimorphic pathways.

The study investigates neurodevelopmental effects of a zebrafish Gal4 transgenic line, finding phenotypes linked to transgene insertion site rather than Gal4 toxicity.

This study examines how the In(2L)t inversion in Drosophila melanogaster affects environmentally sensitive behaviors, showing sex-specific and temperature-consistent impacts on activity, foraging, and startle response.

This paper introduces a method to approximate LD matrices with sparse, banded matrices that are positive semi-definite, improving accuracy over existing methods on large genomic data.

The paper identifies a structural variation in lhcb6 in maize landraces that affects photosystem II maximum quantum efficiency through differential accumulation of LHCII antenna components.

The paper describes an aneuploid Arabidopsis mutant generated by ion beam mutagenesis, showing phenotypic variations and identifying candidate causal genes through transcriptome analysis.

The paper identifies pre-rRNA as a target of Dicer in quiescence and shows RiboCop silences rDNA through histone methylation.

The paper measures the functional impact of over two thousand SOD1 missense variants using saturation mutagenesis and cell-based assays, reclassifying 41% of previously uncertain variants as pathogenic.

The paper identifies a 138-gene transcriptional signature in gastric cancer peritumoral tissue that is conserved in tumors and associated with poor prognosis.

The paper investigates a human-specific VNTR in CACNA1C and shows it modulates neuronal calcium responses and transcription programs.

The paper investigates gene expression patterns caused by transcription factors (TFs) that rescue or fail to rescue specific phenotypes in Drosophila, finding constrained gene regulation despite weak correlation between TFs.

This study identifies BP-modulated genes in retinal tissues linked to EMAP and neurodegeneration, highlighting inflammation and oxidative stress pathways.

The paper examines behavioral variation in cocaine self-administration across multiple phases in genetically diverse mouse populations, identifying strain and sex differences and extreme strains for drug intake traits.

The paper establishes a framework to assess NALCN variant pathogenicity using functional and computational methods, distinguishing benign from gain- and loss-of-function variants.