Anna J. Moyer

The paper identifies dysregulation of cholesterol metabolism as a shared molecular consequence of schizophrenia risk mutations in zebrafish models.

This study inhibits hedgehog signaling in zebrafish embryos by overexpressing Gli3R and identifies transcriptomic changes affecting multiple cell types and ionocyte development.

The study investigates neurodevelopmental effects of a zebrafish Gal4 transgenic line, finding phenotypes linked to transgene insertion site rather than Gal4 toxicity.

The paper identifies cell type-specific regulatory elements in nine mammals and shows their conservation and association with neuropsychiatric and neurodegenerative disease risks.

This study identifies diencephalic and neuropeptidergic dysfunction in zebrafish with autism-risk mutations, revealing potential molecular and behavioral mechanisms.

The paper identifies multiple chromosome 21 genes that modulate Sonic hedgehog signaling, which is dysregulated in Down syndrome.

This paper describes a mouse model with 100% penetrance of AVSD by introducing conditional SHH pathway mutations in a trisomic DS model.

The paper develops a transchromosomic rat model with human chromosome 21 that exhibits key Down syndrome features and provides a tool for DS research and drug development.

This paper describes a new non-mosaic humanized mouse model of Down syndrome with a nearly complete copy of the long arm of human chromosome 21.