David M. Kingsley

Genetic analysis of bone morphometry and ivory vertebrae in threespine stickleback

This study identifies genetic loci influencing bone microstructure and a disease-like phenotype in threespine stickleback fish.

Linked origins but distinct roles for extreme length and sequence variation at a tandem repeat in CACNA1C

The paper examines a tandem repeat in CACNA1C, showing distinct roles of length and sequence variation in disease risk and gene expression.

Rapid and repeated evolution of myosin copy number in threespine stickleback

The paper shows that freshwater threespine stickleback fish have evolved expanded copies of the MYH3C gene family, which is linked to muscle development and adaptive divergence from marine populations.

Human-specific tandem repeat in CACNA1C modulates responses to neuronal stimulation

The paper investigates a human-specific VNTR in CACNA1C and shows it modulates neuronal calcium responses and transcription programs.

The fourspine stickleback (Apeltes quadracus) has an XY sex chromosome system with polymorphic inversions on both X and Y chromosomes

The paper identifies an XY sex chromosome system in fourspine stickleback with polymorphic inversions on both X and Y chromosomes, revealing new insights into sex chromosome evolution.

FOS binding sites are a hub for the evolution of activity-dependent gene regulatory programs in human neurons

The paper identifies human-specific activity-dependent genes regulated by FOS-bound enhancers, showing their role in human brain development evolution.

Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation

The paper uses human-chimpanzee tetraploid cells to identify cis-acting gene regulatory changes contributing to human neural specializations.

Boundary stacking interactions enable cross-TAD enhancer-promoter communication during limb development

The paper investigates cross-TAD enhancer-promoter communication during limb development using ORCA and simulations, finding that boundary stacking enables such interactions and explains architectural stripes.

Characterization of mouse Bmp5 regulatory injury element in zebrafish wound models

The paper identifies a small 142 bp enhancer in the mouse Bmp5 gene that is rapidly induced in injured tissues and responds to conserved signals.

Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia

The paper identifies a human-specific tandem repeat in the CACNA1C gene associated with bipolar disorder and schizophrenia risk, showing it functions as an enhancer with variable activity linked to disease.

An Unexpectedly Complex Architecture for Skin Pigmentation in Africans

The paper shows that skin pigmentation in African populations, particularly the KhoeSan, is highly heritable and polygenic, with many new genetic loci identified beyond previously known ones.