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The paper identifies chromatin-dependent motif syntax that distinguishes binding patterns of NGN2 and MyoD1 during differentiation, revealing how context-specific chromatin states influence transcription factor specificity.

This study evaluates precision and accuracy in sc/snRNA-seq data, identifies factors affecting reproducibility, and introduces a tool to assess data quality and differential expression reliability.

This paper introduces a novel enzymatic strategy using 7-deaza-dGTP and Fpg to remove carryover contamination and improve sequencing performance in NGS.

The paper introduces the GSA Family, a platform for sharing multi-omics and multimodal data, with expanded databases and improved features.

This study shows that maternal exposure to low-level inorganic arsenic increases offspring asthma risk through epigenetic changes, including miR-101c downregulation and TGFβ pathway dysregulation.

This study compares the transcriptomes of adult female and first-stage larvae of Dracunculus medinensis to identify molecular adaptations and potential diagnostic markers.

The paper corrects taxonomic errors in the Fusobacterium nucleatum group, reclassifies Fna C1 as F. watanabei, describes a new species F. paranimalis, and shows virulence genes are widespread across the group.

This paper shows human PGBD5 can interact with four species of piggyBac-like elements and promote their chromosomal integration, similar to insect PB.

TranCi prioritizes noncoding variants by integrating eRNA expression and interactome maps, identifying disease-related mutations in esophageal squamous cell cancer.

This study uses low-pass whole metagenome sequencing to analyze gut microbiome functional capacity and diversity in an Argentine urban population, finding reduced alpha-diversity and impaired metabolic potential in the unscreened cohort.

The paper identifies convergent cis-regulatory elements in hibernators and homeotherms that underlie metabolic responses to fasting and refeeding.

Deletions of conserved cis-elements tied to hibernator evolution causes diverse metabolic traits in mice.

The paper generates complete genome assemblies for Australian Plasmodiophora brassicae isolates and reveals a unique, highly divergent clade with distinct effector profiles.

The paper identifies a centromeric satellite repeat in songbirds and shows it is absent from the germline-restricted chromosome (GRC), suggesting sequence changes underlie its programmed elimination.

The paper identifies candidate imprinting control regions in the dog genome by analyzing CpG-rich motifs and comparing their positions to known ICRs in mouse and human genomes.

The paper presents chromosome-scale genome assemblies for the olive fruit fly and its symbiont, providing foundational resources for genetic research.

This study uses long-read sequencing to detect somatic transposable element mobilization in hypomethylated Arabidopsis thaliana mutants, revealing new mobile elements and variable activity within TE families.

The paper quantifies the role of natural transformation in gene acquisition in bacteria, finding it contributes to a small percentage of novel genes but potentially includes high-impact antibiotic resistance genes.

This paper develops and implements wastewater-based surveillance methods to monitor Influenza A H3N2 and respiratory syncytial virus A in Ontario, Canada, enabling real-time tracking of viral lineages and informing public health decisions.