Chinedu Anthony Anene

Reconstructing the human enhancer RNA transcriptome

The paper reconstructs a transcript-resolved catalogue of human enhancer RNAs, identifies their splice junctions, and provides tools for further study.

Stress-responsive enhancer RNAs couple chromatin reprogramming to post-transcriptional control of senescence

The paper identifies senescence-associated enhancer RNAs (SAeRs) and shows their functional role in linking chromatin reprogramming to post-transcriptional regulation of senescence.

eRNAs Modulate mRNA Stability and Translation Efficiency to Bridge Transcriptional and Post-transcriptional Gene Regulation

The paper characterizes eRNA decay kinetics and identifies their role in modulating mRNA stability and translation efficiency across human cell types.

Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.

This study shows that melanoma cancer-associated fibroblast-derived extracellular vesicles alter the tumor microenvironment and pre-metastatic niche, promoting melanoma metastasis.

Prioritising Functional Noncoding Variants via eRNA Post-transcriptional Interaction Maps in Human Samples

TranCi prioritizes noncoding variants by integrating eRNA expression and interactome maps, identifying disease-related mutations in esophageal squamous cell cancer.

eRNAkit: Expanding the Functional Atlas of human Enhancer RNAs Beyond the Nucleus

eRNAkit integrates subcellular localization, RNA-RNA interaction, and expression data for eRNAs to explore their non-nuclear functions beyond traditional cis-regulatory roles.

Virus-induced paraspeckle-like condensates are essential hubs for gene expression and their formation drives genomic instability

This study shows virus-induced paraspeckle-like structures are critical for viral replication and contribute to genomic instability during KSHV and EBV infections.