Most metagenomic vanT calls are not vancomycin resistance genes
Prateek Shetty, Gergely Maróti, Roland Wirth
The paper shows that most metagenomic vanTG gene calls are misannotations of alanine racemases, not vancomycin resistance genes.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Prateek Shetty, Gergely Maróti, Roland Wirth
The paper shows that most metagenomic vanTG gene calls are misannotations of alanine racemases, not vancomycin resistance genes.
David M. P. De Oliveira, Ruby Heaton, Hayden Whyte…·Brian M. Forde
This study identifies two mechanisms of cefiderocol resistance in Acinetobacter baumannii: cAMP signalling disruption and Hfq RNA-binding domain truncation, both linked to iron homeostasis and reduced drug activity.
Miki Umetani, Mikihiro Hashimoto, Sayo Akiyoshi…·Yuichi Wakamoto
This study shows that antibiotic resistance in E. coli emerges rapidly in single cells under chloramphenicol exposure through phenotypic heterogeneity and gene expression remodeling.
Stephen Blaskowski, Louis Goldwater Christie, Yubin Raut…·E. Virginia Armbrust
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Amaury Le Vern, Charlotte Duval, Jonas Frere…·Sébastien Halary
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Rudan Chen, Weiyue Zhang, Junqi Yu…·Kai Wang
This study identifies core microbiota associated with postlarval survival in shrimp through a meta-analysis of 16S rRNA gene datasets.
Karl de Fine Licht, Michael Martindale, Linda Winnicki…·Cecilia Geijer
This study characterizes honey-associated yeast communities using citizen science, revealing diverse species with osmotolerant and fructophilic traits.
Megan E. Levy, Rechel Geiger, Luc America Chi…·Harmit Singh Malik
This study engineered hMxA to restrict multiple human-adapted influenza viruses as effectively as mMx1 by combining nuclear relocalization and specific amino acid changes.
Caleb R. Carr, Colin J. Mann, Jonathan Abraham, Jesse D. Bloom
This study uses deep mutational scanning to analyze how amino-acid mutations affect the pH stability and cell entry function of the Junin virus glycoprotein complex.
Ann Melissa Campbell, José R W Martínez, Lorena Díaz…·Paul Joseph Planet
The paper reports an increase in USA300-SAE MRSA in Chile, links its spread to environmental copper resistance, and suggests copper exposure may enhance its fitness.
Chloé Haberkorn, Christian I. Oporto, Javier Pinto, Rike Bahati Stelkens
The paper examines microbial community differentiation across a land-water interface, finding strong habitat-associated differences between terrestrial and aquatic samples.
周恕, Colin Sharp, Eleanor R. Gaunt…·Paul Digard
This study investigates the evolutionary flexibility of influenza A virus splicing by testing mutations in SD and SA sites, finding that small changes can activate alternative splicing and produce viable variants with altered ion channel and M1 proteins.
Lu Li, Moemen Hussein, Karen L. Falkner…·Patricia I. Diaz
The paper maps subgingival microbiome states in 1,355 adults, identifying divergent dysbiosis trajectories linked to periodontitis and host factors.
Kevin D. Ricks, Kasturi Bhatt, Megan E. Frederickson
The paper shows that microbial adaptation to environmental stressors can generate benefits to plant hosts, independent of host selection.
Miki X Kawano, Akiho Ohkawa, Napatsorn Suwongsaksri, Akatsuki Saito
This paper develops a synthetic VEEV reporter virus for high-throughput antiviral screening, identifying inhibitors of VEEV replication using FDA-approved compounds.
Elena B. Popowitch, Tommy H. Tran, Isabel F. Escapa…·Matthew S. Kelly
This paper describes two novel Corynebacterium species isolated from human nasal passages and skin, along with characteristics of two strains of a recently named species.
Sangshan Tian, Sumudu Rajakaruna, Gopi Yalavarthi…·Vishal Singh
The paper shows that inulin supplementation increases colon tumor incidence in mice by altering gut microbiome and metabolome, creating a tumor-promoting environment when exposed to carcinogens.
Blake D. Dodson, Mariah E. Thompson, Ryan W. Tibble…·Michael Lagunoff
This study shows that KSHV vFLIP induces lipid droplet formation in TIME cells via NF-κB activation and ACSL activity.
Ryan Adam Valdez, Nina Zheng, Sarah D. Beagle…·Petra Anne Levin
This study identifies multiple non-redundant functions of lipopolysaccharide (LPS) in Gram-negative bacteria, showing it is essential for envelope mechanics, membrane biogenesis, and efflux pump activity.
Jeegna Solanki, Miguel Fernández, Mika Pawitsch…·Nicole Frankenberg‐Dinkel
The paper investigates chromatic acclimation in two Synechococcus species, finding that WH8109 lacks detectable CA4 despite having an intact CA4-B genomic island.