Discover, rate, and discuss biology preprints.

This study identifies distinct roles for Hip14 in regulating acoustic startle sensitivity and habituation through catalytic-dependent and -independent mechanisms in zebrafish neurons.

This study identifies DAB2 as a key regulator linking APOE genotype to microglial state transitions and dementia-risk networks in Alzheimer's disease.

This study identifies critical Ca2+ ligands in synaptotagmin 1 for synaptic vesicle exocytosis and reports mutations affecting function.

Neuralign identifies shared neural patterns across heterogeneous datasets without requiring matched neurons or trials, revealing common structures in motor cortex and mouse brain recordings.

This study evaluates procedural adaptations for automated Patch-seq, showing that automated nucleus extraction and detergent-cleaned pipettes preserve or improve key outcomes.

This study shows that identical movements can form different skills depending on context, observed in both humans and neural networks.

This paper introduces RIDGE, a deconvolution framework that generates spatially continuous cell-type maps of the human cortex, revealing both global organization and regional specialization.

This study shows that GluN2A loss specifically impairs excitatory synaptic integration in hippocampal somatostatin interneurons, affecting EPSP decay and firing without impacting pyramidal or parvalbumin interneurons.

The paper identifies PKR as a critical mediator of mitochondrial neuropathology in a mouse model of Leigh syndrome, showing its role in neuroinflammation and disease progression.

This study shows that speech motor cortex encodes sentence-level linguistic structure and semantic content through single-unit activity in three BrainGate2 participants.

This study introduces DynaClade, an algorithm for analyzing human motion in virtual environments, revealing non-random action sequences with higher-order structure and context-dependent behavior.

This study uses an AAV model to show that aggregation-prone tau variants spread more extensively in the mouse brain, suggesting extracellular vesicles may contribute to tau propagation.

This study shows that postpartum resource scarcity in rats alters maternal behavior, offspring prioritization, and steroid-sensitive brain region structure.

This study examines the extended default mode network (eDMN) in schizophrenia using resting-state fMRI, finding preserved core architecture but altered causal influences in specific regions.

This study shows sleep restores neuronal autophagy in mice, reducing amyloid-beta accumulation and highlighting the role of brain-state timing in proteostasis.

This study shows that task identity is decoded from population activity in the frontal cortex before task-specific stimuli, with conserved geometric representations across tasks, areas, and individuals.

The paper compares TRN and dLGN receptive field properties across cat and mouse to show spatially and temporally tuned inhibition in sensory processing.

OpenDrive provides an open-source microdrive system for high-density neurophysiology recording in large animals, enabling scalable and precise neuronal recordings.

This study identifies cRps6kb1 as a hyperglycemia-responsive circRNA that drives diabetic neuropathic pain by competing with PUM2 for Nt3 3-UTR binding, increasing proNT3/CCL2 expression and nociceptive hypersensitivity.