Xue Zhang

METTL3-mediated m6A modification alleviates skeletal muscle atrophy in ALS by regulating ACSL1-dependent triglyceride metabolism

This study identifies METTL3-mediated m6A modification as a regulator of triglyceride metabolism in ALS skeletal muscle, alleviating atrophy through ACSL1 expression.

CHORD: a framework for cross-species single-cell integration across gene, cell and cell-type levels

CHORD integrates cross-species single-cell transcriptomic data to learn gene, cell, and cell-type representations, enabling cell-type annotation and cross-species comparison of developmental and phenotypic patterns.

Genetic loss of JAK1 and cutaneous HPV infection

The paper identifies JAK1 loss-of-function variants in patients with epidermodysplasia verruciformis, linking them to susceptibility to cutaneous HPV infection and impaired antiviral immunity.

MetaSAG: A Tool for Multi-level Exploration and Taxonomic Analysis of Microbial Single-Amplified Genomes

MetaSAG provides a tool for multi-level analysis of microbial single-amplified genomes, improving taxonomic classification and enabling functional and evolutionary insights.

Germline intergenic duplications at Xq26.1 underlie Bazex-Dupre-Christol syndrome, an inherited basal cell carcinoma susceptibility condition

The paper identifies intergenic duplications at Xq26.1 as the genetic cause of Bazex-Dupre-Christol syndrome, linking them to ARHGAP36 dysregulation and BCC susceptibility.

Codon-optimized FAM132b prevents diet-induced obesity by modulating adrenergic response and insulin action

This paper shows that codon-optimized FAM132b gene therapy via AAV9 reduces obesity and improves glucose homeostasis in mice by modulating adrenergic response and insulin action.