Luke Campagnola

This paper creates a cross-species spatial transcriptomic atlas of the basal ganglia in human, rhesus macaque, and common marmoset, revealing conserved molecular organization and cell type-specific compartments.

The paper investigates how electric fields affect different cortical neuron classes, finding frequency-dependent entrainment and class-specific responses in rodent and human neurons.

This paper introduces a simple synaptic learning mechanism that enables a neural network to detect novelty in three distinct forms, demonstrating how basic plasticity can generate diverse novelty responses.

The paper investigates the synaptic connectivity of thick tufted layer 5 pyramidal neurons in the mouse visual cortex, revealing their local inhibitory and long-range excitatory connections.

The paper investigates target cell-specific synaptic dynamics between excitatory and inhibitory neurons in human neocortex, finding similarities to rodent studies.

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

The paper presents a synaptic physiology dataset and analysis platform to study cortical microcircuit structure and synaptic properties in mouse and human neocortex, revealing layer-dependent connectivity and subclass-specific dynamics.

The paper measures synaptic inputs onto superficial excitatory neurons in mouse primary visual cortex using two-photon optogenetic stimulation and finds that layer 4 excitatory neurons and somatostatin-neurons in layer 2/3 are the most common sources of input, with strong connections distributed across cells.

The paper shows that recurrent synaptic networks in the mouse cortex strongly control neural activity dimensionality across time and brain areas, mediated by cell-type specific network motifs present in both mouse and human brains.

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

The paper characterizes short-term synaptic plasticity patterns in mouse synapses and finds diverse STP types with distinct postsynaptic responses.

The paper examines sparse excitatory connectivity in adult mouse and human cortex using electrophysiology and optogenetics, finding sparse connections and synaptic dynamics across layers.