Alexis‐Pierre Bemelmans

The paper introduces a Gateway-based cloning platform for efficient construction of rAAV vectors optimized for neuroscience applications, enabling precise optical interrogation of neural circuits with tools like ULoVE.

The paper identifies astrocyte perisynaptic processes as sites of early translational dysregulation in Alzheimer's disease, linking it to synaptic dysfunction and disease initiation.

The paper shows that astrocytes regulate maternal behavior through connexin 30, affecting oxytocin levels and synaptic structure in the hypothalamus of female mice.

This study shows that astroglial Ophn1 deficiency impairs synaptic transmission and behavior, with potential therapeutic targeting of the RhoA/ROCK pathway.

This study fine-tunes FAM161A gene therapy in mice to restore retinal function by optimizing promoter activity, dosage, and isoform delivery.

This study identifies RACK1 as a repressor of KIR4.1 translation in astrocytes, showing its role in regulating neuronal activity through modulation of KIR4.1 expression.

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

The paper shows dendritic spines refill ER calcium stores through controlled calcium entry without depletion, using computational modeling and imaging.

The paper shows disrupting D2-NMDA receptor heteromerization blocks cocaine's rewarding effects without affecting natural reward processing in mice and humans.

The paper shows astroglial glutamine supply is essential for synaptic activity and memory via connexin43-mediated transport.

This study identifies astrocytes as key regulators of critical period closure in the mouse visual cortex through connexin 30-mediated inhibition of MMP9.

The paper identifies a unique molecular repertoire in hippocampal perisynaptic astrocytic processes, regulated by local translation during fear conditioning.

The paper identifies a mechanism by which VGLUT1 increases synaptic vesicle clustering, reducing superpool size and spontaneous release frequency through interactions with endophilinA1 and intersectin1.

This study investigates the role of reactive astrocytes in Alzheimer's disease by modulating the JAK2-STAT3 pathway in 3xTg-AD mice, finding no effect on Tau or amyloid pathology but behavioral changes.