Discover, rate, and discuss biology preprints.

The paper develops molecular tools to detect and identify Pseudomonas syringae strains causing zucchini vein clearing by designing primers and qPCR tests for specific genetic clusters.

This study uses cryo-electron tomography to examine the in situ structure of beta-amyloid and tau in Alzheimer's disease brain tissue, revealing distinct structural features and spatial organization.

This study quantifies retinal tau isoforms in early and advanced AD and links them to brain pathology and cognitive status.

This study evaluates Gremlin-1 as a therapeutic target in MASH fibrosis, finding it upregulated but not amenable to targeting due to its restricted expression and lack of effect on fibrogenesis.

This study identifies early microvascular damage in diabetic retinas before clinical DR diagnosis and finds no spatial correlation between capillary dropout and neural cell loss in the inner nuclear layer.

The paper identifies a redox-shifted fibroblast subpopulation in fibrotic lungs, showing increased pro-fibrotic activity and reduced collagenolytic activity.

This study uses deep learning to classify ex vivo human colon tissues with spectroscopic OCT, achieving 88.9% accuracy in distinguishing tissue types.

This paper measures aortic rupture force in mouse models of hereditary aortic diseases to assess biomechanical integrity and drug effects.

This paper demonstrates HiP-CT's ability to image adult human hearts at multiple scales, revealing structural details in health and disease.

The paper quantifies retinal perivascular amyloid plaque distribution in relation to cognitive performance, finding higher peri-arteriolar amyloid burden and correlations with cognitive decline.

This study shows that PM2.5 exposure worsens IRI-induced AKI in mice by increasing tubular damage, immune activation, and fibrosis markers.

This study shows that chP3R99 reduces lipoprotein retention in insulin-resistant rats through acute treatment or long-term vaccination, with no adverse metabolic effects.

The paper compares microbiota and metabolome profiles of quiescent Crohn's disease patients with their healthy first-degree relatives to identify biomarkers associated with disease relapse.

This study investigates FAP expression in human deep venous thrombus, finding it localized in fibroblasts and macrophages during organizing reactions.

This study shows short-term statin treatment reduces chronic vascular injury from radiation therapy in mice, while long-term treatment fully reverses it.

The paper identifies B-cell gene expression pathways and imaging biomarkers associated with asymptomatic Mycobacterium tuberculosis infection in mice.

This study shows that the TB-associated microenvironment suppresses HIV-1 replication and promotes latency in CD4+ T cells from HIV-1 patients.

This study identifies glycoprotein VI as a critical factor in AAA detection and progression, showing its predictive value in humans and therapeutic potential in mice.

The paper models disease progression in Lewy body disorders using neuropathological data, identifying three distinct trajectories of alpha-synuclein pathology with different clinical associations.