Author

Paul Horn

Berlin Institute of Health at Charité - Universitätsmedizin BerlinORCID 0000-0002-8755-7703Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Adrien GuillotiD· 1 shared Alexander MaltiD· 1 shared Bernhard DrotleffiD· 1 shared Brian LongiD· 1 shared Christian von LoeffelholziD· 1 shared Christoph KuppeiD· 1 shared Elisa JenthoiD· 1 shared Fabian Joachim TheisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Adrien GuillotORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

2D, or not 2D? Investigating Vertical Signal Integrity of Tissue Slices

Sebastian Tiesmeyer, Niklas Müller‐Bötticher, Alexander Malt, Leyao Ma, Sergio Marco Salas, Paul Kießling, Paul Horn, Adrien Guillot, Louis Benedikt Kuemmerle, Frank Tacke, Fabian Joachim Theis, Christoph Kuppe, Mats F. Nilsson, Roland Eils, Brian Long, Naveed Ishaque

This paper introduces a tool to detect overlapping cells and segmentation errors in 3D spatial transcriptomics data.

Nature Biotechnology · Feb 10, 2026Peer-reviewedBioinformatics

A bioenergetic basis for multiorgan dysfunction in sepsis

Elisa Jentho, Temitope Wilson Ademolue, Hessel Peters Sengers, Joe M. Butler, Linlin Xu, Sharad Rastogi, Jamil Zola Kitoko, Sara Emanuela Pagnotta, Bernhard Drotleff, Pedro Faísca, Valentyna O. Polishchuk, Miguel Mesquita, Paul Horn, Uta Barbara Metzing, Sílvia Cardoso, , Miguel Parreira Soares

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

bioRxiv · Jun 12, 2025 · PreprintPathology