Rene A. W. Frank

The paper visualizes the 3D molecular architecture of engram synapses in the mouse hippocampus using cryoCLEM-guided cryoET to study synaptic plasticity in memory formation.

This study reveals the in-tissue molecular architecture of β-amyloid fibrils in a mouse model of Alzheimer's disease, showing their arrangement in lattices and their structural differences due to the Arctic mutation.

This study uses cryo-electron tomography to reveal the 3D molecular architecture of glutamatergic synapses in the adult mammalian forebrain, showing a synaptoplasm rather than a distinct PSD.