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This study uses gain- and loss-of-function models of the mitochondrial calcium uniporter to show that mCa2+ uptake is essential for early cardiac contractility but harmful under sustained stress.

This study compares the vascular phenotypes and transcriptional states of Notch pathway mutants, revealing discrepancies between molecular changes and vascular pathology.

The paper shows acid enhances salt taste by modulating ENaC channel activity, with acidic beverages like Coca-Cola and Pepsi stimulating ENaC current while Diet Coke does not.

This study examines cardiovascular responses to mechanical noxious stimuli in chicken embryos, finding nociceptive responses emerge by ED16-ED18 with lidocaine reducing MAP changes on ED18.

The paper develops a method to predict hERG repolarization power at 37°C using room temperature recordings to accelerate variant functional characterization.

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

This study investigates how auditory midbrain and cortex process statistical features of natural sound textures using texture morph stimuli in anesthetized rats, finding that the midbrain encodes these features more effectively than the cortex.

This study investigates CO2 detection in earthworms using an exudate assay and pharmacological inhibitors, identifying carbonic anhydrase and sodium channels as key players.

The paper investigates whether the spatial autocorrelation dimension (Di) predicts the time to termination of human atrial and ventricular fibrillation.

This study shows that obese female mice have suppressed vascular Rho-kinase activation, which protects against cardiovascular issues, unlike male mice.

This study examines how environmental conditions affect antioxidant levels in sea oat seeds, finding that extreme climates correlate with higher baseline antioxidants, while imbibition-induced antioxidants relate to poor germination in warm conditions.

The paper uses SSVEP to measure SNARC-spatial attention effects during a parity judgment task, finding larger amplitude differences in congruent conditions.

This study shows that extreme heat stress reduces male fertility in Antarctic mites, potentially leading to population declines.

This study examines how acute exercise affects multi-omics profiles in skeletal muscle of trained and untrained individuals, revealing distinct metabolic and transcriptional responses based on training history and exercise type.

The paper identifies Kir7.1 as the target of steroids regulating uteroplacental function, showing its activation by progesterone and labor-prevention drugs.

This study shows that inhibiting somatostatin signaling improves and sustains metabolic benefits after sleeve gastrectomy in mice.

This paper compares the accuracy of two cardiac tissue models, finding the EMI model better captures refractory behavior than the bidomain model.

This study shows that reducing mitochondrial oxidative stress with an antioxidant improves insulin sensitivity in human muscle under lipid overload conditions.

This paper shows that mavacamten stabilizes myosin in off states, which can still be recruited by physiological inotropic effectors to maintain cardiac function.

This study shows miR-125b-5p regulates ESCRT-dependent EV biogenesis and trafficking in porcine trophoblasts, affecting EV subpopulation release during implantation.