C. Henriquez-Olguin

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans

This study shows that reducing mitochondrial oxidative stress with an antioxidant improves insulin sensitivity in human muscle under lipid overload conditions.

Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle

This study shows that microtubule disruption impairs GLUT4 trafficking in skeletal muscle, contributing to insulin resistance.

Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion

This study shows cancer reduces insulin-stimulated glucose uptake in muscle and adipose tissue and impairs muscle microvascular perfusion in mice.

Phosphoproteomic identification of Xin as a novel requirement for skeletal muscle disuse atrophy

This study identifies Xin as a novel protein involved in skeletal muscle disuse atrophy using phosphoproteomic analysis and confirms its regulation in mice and humans.

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

This study shows that follistatin overexpression in muscle improves insulin-stimulated glucose uptake and protein synthesis, and that circulating follistatin increases after bariatric surgery, suggesting its role in insulin sensitivity.

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

This study shows that NOX2 produces cytosolic ROS in skeletal muscle during exercise, which regulates glucose uptake and GLUT4 translocation.

NADPH-oxidase 2 is required for molecular adaptations to high-intensity interval training in skeletal muscle.

This study shows that NOX2 is necessary for skeletal muscle adaptations to high-intensity interval training, including antioxidant defense and mitochondrial changes.