Author

P. V. Lishko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 2 Physiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Approach:microscopy & imaging analysis· 3 Assay:cryo-EM· 2

Frequent Co-Authors

K. Xu· 2 shared S. Mendoza· 2 shared W. M. Skinner· 2 shared A. M. Bertholet· 1 shared A. Modzelewski· 1 shared B. Unger· 1 shared C. Guo· 1 shared C. Vergara· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

K. Xu

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Author profile →

8 papers

Recent·Most cited

Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function

M. Haoui, C. Vergara, P. V. Lishko

The paper identifies Kir7.1 as the target of steroids regulating uteroplacental function, showing its activation by progesterone and labor-prevention drugs.

bioRxiv · Apr 11, 2023Physiology

Mitochondrial uncouplers impair human sperm motility without altering ATP content

W. M. Skinner, N. T. Petersen, B. Unger, S. Tang, E. Tabarsi, J. Lamm, L. Jalalian, J. Smith, A. M. Bertholet, K. Xu, Y. Kirichok, P. V. Lishko

This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.

bioRxiv · Aug 4, 2022Cell Biology

In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes

Z. Chen, G. A. Greenan, M. Shiozaki, Y. Liu, W. M. Skinner, X. Zhao, S. Zhao, R. Yan, C. Guo, Z. Yu, P. V. Lishko, D. A. Agard, R. D. Vale

This study uses cryo-electron tomography to reveal the asymmetric protein complexes in mammalian sperm axonemes, explaining their unique flagellar beating pattern.

bioRxiv · May 15, 2022Biophysics

3D structure and in situ arrangements of CatSper channel in the sperm flagellum

Y. Zhao, H. Wang, C. Wiesehoefer, N. B. Shah, E. Reetz, J. Y. Hwang, X. Huang, P. V. Lishko, K. M. Davies, G. Wennemuth, D. Nicastro, J.-J. Chung

This study uses cryo-electron tomography to reveal the 3D structure and arrangement of the CatSper channel complex in mammalian sperm, identifying new associated proteins and structural features critical for flagellar function.

bioRxiv · Jun 19, 2021Biophysics

The impact of di-2-ethylhexyl phthalate on sperm fertility

L. Gabelev Khasin, J. Dell Rosa, N. Petersen, J. Moeller, L. J. Kriegsfeld, P. V. Lishko

This study investigates the acute effects of DEHP on male fertility, finding it impairs sperm capacitation, acrosome reaction, and increases ROS production.

bioRxiv · Apr 9, 2020Pharmacology & Toxicology

Alpha/Beta Hydrolase Domain-Containing Protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle

I. Björkgren, D. H. Chung, S. Mendoza, L. Gabelev-Khasin, A. Modzelewski, L. He, P. V. Lishko

This study identifies ABHD2 as a novel non-genomic regulator of the female reproductive cycle, showing its role in follicular maturation and estrous cycle regulation through experiments in knockout mice.

bioRxiv · Jul 2, 2019Physiology

Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation

M. Miller, S. Kenny, N. Mannowetz, S. Mansell, M. Wojcik, S. Mendoza, R. Zucker, K. Xu, P. V. Lishko

The paper identifies Hv1 and CatSper nanodomains in human sperm that regulate flagellar rotation and hyperactivated motility through asymmetric positioning.

bioRxiv · Mar 27, 2018Cell Biology

TRPV4 is the temperature-sensitive ion channel of human sperm

N. Mundt, M. Spehr, P. V. Lishko

The paper identifies TRPV4 as the temperature-sensitive ion channel DSper in human sperm, which mediates initial membrane depolarization and activates downstream ion channels.

bioRxiv · Feb 20, 2018Cell Biology