Author

J. W. Elrod

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. F. Garbincius· 3 shared P. Jadiya· 3 shared A. N. Hildebrand· 2 shared A. S. Mangold· 2 shared C. Choya-Foces· 2 shared D. Tomar· 2 shared E. K. Murray· 2 shared J. P. Lambert· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersPhysiology

J. F. Garbincius

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

TMEM65 regulates NCLX-dependent mitochondrial calcium efflux

J. F. Garbincius, O. Salik, H. M. Cohen, C. Choya-Foces, A. S. Mangold, A. D. Makhoul, A. E. Schmidt, D. Y. Khalil, J. J. Doolittle, A. S. Wilkinson, E. K. Murray, M. P. Lazaropoulos, A. N. Hildebrand, D. Tomar, J. W. Elrod

This study identifies TMEM65 as a regulator of NCLX-dependent mitochondrial calcium efflux, showing its role in preventing calcium overload and cell death in excitable tissues.

bioRxiv · Oct 6, 2023Physiology

MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure

J. F. Garbincius, T. S. Luongo, J. P. Lambert, A. S. Mangold, E. K. Murray, A. N. Hildebrand, P. Jadiya, J. W. Elrod

This study uses gain- and loss-of-function models of the mitochondrial calcium uniporter to show that mCa2+ uptake is essential for early cardiac contractility but harmful under sustained stress.

bioRxiv · Apr 17, 2023 · PreprintPhysiology

Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance

J. V. Cabral-Costa, C. Vicente-Gutierrez, J. Agulla, R. Lapresa, J. W. Elrod, A. Almeida, J. P. Bolanos, A. J. Kowaltowski

This study shows that NCLX in astrocytes affects glycolysis and cognitive performance, with different impacts based on cell type.

bioRxiv · Sep 16, 2022Biochemistry

Mitochondrial Na+ controls oxidative phosphorylation and hypoxic redox signalling

P. Hernansanz-Agustin, C. Choya-Foces, S. Carregal-Romero, E. Ramos, T. Oliva, T. Villa-Pina, L. Moreno, A. Izquierdo-Alvarez, J. D. Cabrera-Garcia, A. Cortes, A. V. Lechuga-Vieco, P. Jadiya, E. Navarro, E. Parada, A. Palomino-Antolin, , A. Martinez-Ruiz

This study shows that mitochondrial Na+ acts as a second messenger regulating OXPHOS and ROS production through interactions with phospholipids during hypoxia.

bioRxiv · Oct 31, 2019Biochemistry

MICU1 regulates mitochondrial cristae structure and function independent of the mitochondrial calcium uniporter channel

D. Tomar, M. Thomas, J. F. Garbincius, D. W. Kolmetzky, O. Salik, P. Jadiya, A. C. Carpenter, J. W. Elrod

This paper identifies mtCU-independent functions of MICU1, showing it regulates mitochondrial cristae structure and function through interactions with MICOS components.

bioRxiv · Oct 12, 2019Cell Biology

Abcg2-Expressing Side Population Cells Contribute to Cardiomyocyte Renewal through Fusion

J. H. van Berlo, A. Yellamilli, Y. Ren, R. T. McElmurry, J. P. Lambert, P. Gross, S. Mohsin, S. R. Houser, J. W. Elrod, J. Tolar, D. Garry

This study identifies Abcg2-expressing side population cells in the heart that contribute to cardiomyocyte renewal via fusion rather than direct differentiation following injury.

bioRxiv · Jul 2, 2019Cell Biology