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This paper develops and validates sex-specific computational models of human atrial cardiomyocytes to investigate sex differences in atrial fibrillation mechanisms and therapeutic responses.

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

This study uses machine learning to predict antimicrobial peptides (AMPs) for ulcerative colitis therapy, showing improved disease parameters in a mouse model.

This study shows shear stress increases ABCA1 expression and reduces endothelial cell membrane cholesterol, promoting H2S-mediated vasodilation.

This study examines how temperature affects flight performance in two stingless bee species and how their geographic ranges influence their thermal performance curves.

This study shows PGC-1α overexpression in skeletal muscle changes mitochondrial lipid composition but does not improve ATP synthesis efficiency.

This study compares thermal tolerance and DNA damage in Arctic copepod Calanus hyperboreus and temperate copepods from the Oslofjord, finding C. hyperboreus more tolerant to higher temperatures.

The study shows that enteral OCA prevents cholestasis and intestinal atrophy in neonatal pigs by enhancing bile acid and sterol transport through FXR target genes, with additional intestinal growth benefits.

This study compares proactive balance control during treadmill accelerations between stroke patients and healthy individuals, finding reduced COM speed reduction in stroke patients.

This study identifies Pvf1-PvR signaling between the trachea and gut that guides intestinal stem cell migration during regeneration.

This study examines muscle strength and protein turnover in a rodent model of anorexia nervosa, finding that muscle strength remains impaired after recovery.

This study identifies a missense variant in FXR that impairs its conformational transition to an active state, leading to reduced BSEP expression and a PFIC phenotype.

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

This study investigates diurnal regulation of urinary behavior and gene expression in aged mice, finding disrupted circadian rhythms and loss of Piezo1 regulation in bladder tissues.

This study shows that galantamine reduces inflammation and improves outcomes in a mouse model of ARDS.

This study investigates the role of the male duck syringeal bulla in courtship vocalizations by analyzing resonance frequencies and comparing them to vocalization spectra.

This study shows that glucagon receptor signaling is essential for the healthspan benefits of caloric restriction in aging male mice, as its absence reduces lifespan and impairs metabolic improvements.

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

A marsh samphire extract extends female Drosophila lifespan and reduces body fat, with effects dependent on Tor signaling and counteracting intestinal barrier loss.