Ran Hee Choi

This study shows that semaglutide causes muscle loss in male ob/ob mice but not in female ob/ob mice, revealing sex-specific effects on skeletal muscle mass and metabolism.

This study shows PGC-1α overexpression in skeletal muscle changes mitochondrial lipid composition but does not improve ATP synthesis efficiency.

This study shows that TRB3 overexpression in skeletal muscle reduces exercise-induced adaptations by impairing glucose metabolism and mitochondrial biogenesis.

The paper develops a method to profile mitochondrial function in specific kidney segments from mice and humans under thermodynamic control, revealing segment-specific bioenergetic differences.

This study shows semaglutide improves mitochondrial energy efficiency in skeletal muscle by enhancing ATP production per oxygen consumed during weight loss.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.