Author

Alphy John

University of CopenhagenORCID 0000-0003-1319-3799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:simulation· 1

Frequent Co-Authors

Ditte S. AnderseniD· 2 shared Julien ColombaniiD· 2 shared Matteo RauziiD· 2 shared Abdul Basith TanariiD· 1 shared Alexandre L. TorzynskiiD· 1 shared Amin DoostmohammadiiD· 1 shared Anna PopkovaiD· 1 shared B. Delorme· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

Ditte S. AndersenORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 18, 2026

Higher-Order Mechanical Neighbourhood Sensing Governs Cell Fate in Complex Tissues

Alphy John, Tianxiang Ma, Duncan J. D. Mackay…·Ditte S. Andersen

The paper identifies a higher-order mechanical neighbourhood-sensing mechanism in Drosophila midgut that integrates cell identity and mechanics to regulate stem cell fate.

DOI 10.64898/2026.08.13.744616

Drosophilastatistical model

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PhysiologyNature CommunicationsPeer-reviewedSep 29, 2025

Pvf1-PvR-mediated crosstalk between the trachea and the gut guides intestinal stem cell migration to promote gut regeneration.

D. J. Mackay, Alphy John, Christian Christensen…·Ditte S. Andersen

This study identifies Pvf1-PvR signaling between the trachea and gut that guides intestinal stem cell migration during regeneration.

4 citations

Drosophilaexperimental assay

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Developmental BiologyNature CommunicationsPeer-reviewedJun 10, 2022

Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation

Julien Fierling, Alphy John, B. Delorme…·Matteo Rauzi

The paper shows that tissue-scale force balance, not cell-autonomous shape changes, drives epithelial buckling and initiates gastrulation in Drosophila embryos.

36 citationstop 3%

Drosophilaimaging

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