Discover, rate, and discuss biology preprints.

The paper presents a serverless cloud computing approach for scRNA-seq data processing, demonstrating significant speedup for large datasets.

This study shows Salmonella enterica can produce 1,3-propanediol from crude glycerol using the propanediol utilization pathway without high cofactor concentrations.

This study identifies differentially expressed genes associated with flowering-time variation in coffee genotypes, linking them to hormonal regulation and floral development pathways.

This study identifies PRRT2 as a regulator of Nav channel slow inactivation, showing its role in maintaining cortical resilience to hyperexcitability.

The paper evaluates the reproducibility of diffusion, shape, and connectivity metrics across scanners in multi-site tractography studies and finds shape metrics show the highest reproducibility.

This study develops a mathematical model to show how curvature-dependent tissue growth arises from cell crowding and mechanical interactions, predicting pore closure scaling with size and shape.

This study examines how selective logging affects genetic diversity and seedling recruitment in Dicorynia guianensis, finding no genetic erosion but altered dispersal and reproductive patterns.

This paper describes the embryonic development of the convict cichlid from fertilization to hatching, providing a staging table for comparative developmental studies.

This study compares metabarcoding and individual barcoding of insect samples, finding they yield similar community structure but metabarcoding adds more species due to DNA residues.

The paper reports three new populations of the Critically Endangered Khasi Hill Toad, expands its known geographic range, and provides molecular data on genetic and morphometric variation.

The paper models how balancing selection can extend its diversity-promoting effects to loci with sign epistasis, showing dominance and recombination rate are key factors.

This study shows that high intensity interval training (HIIT) preserves physical, cognitive, and cardiovascular function in older female mice and reduces frailty.

This study compares divergent and unidirectional transcriptional regulatory elements, finding that unidirectional elements are younger and less constrained, with some transcription factors modulating their directionality.

The paper models and analyzes growth bistability in small E. coli populations exposed to ciprofloxacin, showing heterogeneous responses at the single-cell level.

This study uses multimodal imaging to show that rhizosphere oxygen levels in rice are linked to root growth stage and thickness, with genotypic differences observed in oxidation despite root thickness variations.

This paper refines an in vitro protocol for culturing schistosomes to achieve sexual dimorphism, showing that human serum promotes red blood cell digestion and sexual differentiation compared to fetal bovine serum.

The paper identifies MIKC MADS-box transcription factors ABS/TT16 and STK as regulators of maternal nutrient flow during ovule maturation and seed development in Arabidopsis.

This paper describes a community-based participatory approach involving adolescents to co-design research priorities for a population neuroimaging research programme, identifying mental health and stress as top priorities.

This study identifies urinary proteomic signatures associated with subclinical AKD following nephrotoxic or ischemic injury in rats, revealing persistent structural damage despite functional recovery.

This study identifies a novel paralog interplay between p190A and p190B in endometrial cancer, showing synthetic lethality and actin remodeling effects upon their removal.