You Chen

Directionality of Transcriptional Regulatory Elements

This study compares divergent and unidirectional transcriptional regulatory elements, finding that unidirectional elements are younger and less constrained, with some transcription factors modulating their directionality.

The nascent transcriptome delineates the regulatory landscape in human health and disease

The paper presents a high-resolution atlas of transcriptional regulatory elements in human tissues and disease states using PRO-cap and deep learning models to prioritize noncoding variants.

Capped nascent RNA sequencing reveals novel therapy-responsive enhancers in prostate cancer

This study uses PRO-cap to identify drug-responsive enhancers in prostate cancer, finding many not detected by ChIP-seq or ATAC-seq.

A 3D Structural Interactome to Explore the Impact of Evolutionary Divergence, Population Variation, and Small-molecule Drugs on SARS-CoV-2-Human Protein-Protein Interactions

The paper constructs a 3D structural interactome of SARS-CoV-2-human protein interactions, analyzing evolutionary divergence, population variation, and drug impacts.