Gabriel Rinaldi

Schistosoma mansoni infection enhances insertion sequence activity in the host gut microbiome

This study shows that Schistosoma mansoni infection increases insertion sequence activity in the gut microbiome of mice, suggesting enhanced microbial genome plasticity.

In vitro sexual dimorphism establishment in schistosomes

This paper refines an in vitro protocol for culturing schistosomes to achieve sexual dimorphism, showing that human serum promotes red blood cell digestion and sexual differentiation compared to fetal bovine serum.

Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

This study uses single-cell RNA sequencing to show that T. cruzi trypomastigote cells express trans-sialidase-like superfamily genes with high heterogeneity and no recurrent combinations.

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery.

A cytochrome P450 humanised mouse model is used to study Schistosoma mansoni development, schistosomiasis, drug metabolism and drug efficacy.

A single-cell atlas of the miracidium larva of the human blood fluke Schistosoma mansoni: cell types, developmental pathways and tissue architecture

Single cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem cell regulators.

The paper performs single-cell transcriptomics on the first intra-molluscan stage of Schistosoma mansoni to identify key cell type regulators and their biological processes.

Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni

This study identifies daily transcriptomic rhythms in Schistosoma mansoni, revealing rhythmic gene expression patterns and their potential relevance to parasite survival and drug targets.

The transcriptome of Schistosoma mansoni developing eggs reveals key mediators in pathogenesis and life cycle propagation.

This study analyzes the transcriptome of Schistosoma mansoni developing eggs to identify genes involved in pathogenesis and life cycle progression.

Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system

The paper assembles the chromosomes of Schistosoma mansoni, revealing insights into the evolution of its ZW sex-determination system through gene annotation and synteny analysis.

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

This study creates a single-cell RNA sequencing atlas of the early intra-mammalian stage of Schistosoma mansoni, identifying gene expression profiles and validating cell markers.

Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni

This study uses CRISPR-Cas9 to induce deletions in the SULT-OR gene of Schistosoma mansoni, showing potential for oxamniquine resistance but limited mRNA knockdown due to low mutation frequency.

Evidence for transposable element control by Argonautes in a parasitic flatworm lacking the piRNA pathway.

The paper shows that Ago proteins in Schistosoma mansoni control retrotransposable elements, despite lacking the piRNA pathway.

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

This paper demonstrates CRISPR/Cas9-based genome editing in Schistosoma mansoni, successfully mutating the omega-1 gene and reducing Th2 cytokine responses and granuloma formation.

Comparative genomics of the major parasitic worms

This paper compares genomes of 81 nematode and platyhelminth species to identify gene families related to parasitism and prioritize new drug targets.