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Genome-scale modelling and stable isotope tracing reveal dynamic metabolic reprogramming in a human cardiac hypertrophy model

The paper uses genome-scale modelling and stable isotope tracing to study metabolic changes in human cardiac hypertrophy models.

Allele-agnostic KCNH1 suppression rescues gain-of-function developmental epileptic encephalopathy

This study shows that suppressing KCNH1 rescues seizures and developmental issues caused by gain-of-function variants in KCNH1.

Functional analysis enables reclassification of SCN1A missense variants of uncertain significance in epilepsy

This paper uses automated patch-clamp assays to reclassify SCN1A missense variants, changing classifications for 50% of tested variants.

Human medial frontal neurons represent integrated semantic content and sensory evidence to inform decision-making

The paper identifies how medial frontal cortex integrates semantic content and sensory evidence for decision-making using human neurosurgical data and a vision-language model.

RabbitCD-HIT: Distributed High-Sensitivity Greedy Incremental Clustering for Billion-Scale Protein Sequences in Hours

RabbitCD-HIT clusters billion-scale protein sequences efficiently, achieving faster performance than CD-HIT on large datasets.

Testing and training geometrical knowledge in baboons through a conceptual categorization task

This study trains baboons on geometric concepts and finds they can learn geometric properties but do not show human-like sensitivity to geometric regularity in shape recognition tasks.

A single-cell transcriptomic atlas of the pigtail macaque lung

This paper constructs a single-cell transcriptomic atlas of the pigtail macaque lung, revealing high similarity to human lung cell types and providing a reference for studying respiratory diseases in a translational model.

Visual capture of the head-direction signal in a rat model of Fragile X Syndrome

The paper examines altered sensory integration in a rat model of Fragile X Syndrome, finding enhanced visual capture and reduced self-motion processing in the head-direction system.

Tardigrades survive reversible dormancy during spaceflight: In-orbit revival, post-flight recovery, and transcriptomic responses

This study shows that tardigrades can survive and revive after spaceflight, with transcriptomic changes indicating stress responses and reduced energy metabolism.

Assembly of host-specific bacterial and fungal communities from soil by diverse subaerial green algae

This study shows subaerial green algae from Chlorophyta and Streptophyta assemble distinct phycosphere communities from soil, with host identity driving bacterial composition more strongly than fungal.

Investigating the potential effect of topiramate on anorexia nervosa and binge eating behaviour using drug-target Mendelian randomization

This study uses Mendelian randomization to assess if topiramate affects anorexia nervosa and binge eating risk, finding a potential link with binge eating but not anorexia.

Proliferation and mutation as humoral immune response

This study models the affinity maturation process to assess the roles of proliferation and mutation in the humoral immune response, finding that multiple strategies can yield optimal outcomes.

StableProt: Structure-Aware Deep Learning for Protein Thermostability (Tm) and Environmental Adaptation (OGT) Prediction

StableProt predicts protein thermostability and organismal optimal growth temperature using a structure-aware deep learning framework, achieving high accuracy and robustness across temperature regimes.

Three-dimensional mapping of human lung fibrosis identifies spatial coupling between tissue microarchitecture and maladaptive repair states

This study maps human lung fibrosis in 3D, showing how structural changes in tissue microarchitecture drive maladaptive repair states and disease progression.

SPACE-Tag Enables High-Throughput Spatial Chromatin Profiling With CUT&Tag

The paper introduces SPACE-Tag, a spatial CUT&Tag method for chromatin profiling, and applies it to the mouse brain to reveal age-related chromatin and transcriptome changes.

Microbially conjugated bile acids differentially affect the lifecycle and pathogenesis of Clostridioides difficile

The paper synthesizes and tests microbially conjugated bile acids (MCBAs) to determine their effects on Clostridioides difficile lifecycle stages, revealing amino acid-dependent inhibitory or promoting effects.

The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

Feasible closed-loop stimulation for neural latent dynamics control

This study uses simulations to show that low-dimensional optogenetic stimulation can effectively control neural latent dynamics with fewer channels than neurons, guiding future hardware design.

Proteome-wide discovery of novel diagnostic antigens for coccidioidomycosis

This study identifies novel diagnostic antigens for coccidioidomycosis using high-dimensional peptide serology, showing improved accuracy in distinguishing infected individuals from controls.

Citrobacter rodentium infection disrupts colonic mucus barrier function via ablation of intercrypt goblet cells

This study shows that Citrobacter rodentium infection disrupts the colonic mucus barrier by ablating intercrypt goblet cells, leading to impaired barrier integrity and enhanced pathogen colonization.