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This paper develops a tumor-targeting engineered bacterium that improves therapeutic efficacy and safety in cancer treatment.

The study investigates the diet of the brood mite Proctotydaeus furnarius, finding it consumes fungi but may also feed on host brood.

This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.

The paper analyzes genomic data from UK black alder populations to identify loci associated with environmental adaptation and assesses maladaptation risks under climate change.

This study investigates how rice genotype, root compartment, and mycorrhizal association influence root microbiome composition in flooded conditions using shotgun metagenomic sequencing.

This study uses functional ultrasound imaging to map brain and spinal cord activity during micturition in rats, revealing region-specific hemodynamic responses and decoding bladder pressure dynamics.

This study identifies Esyt1 as a scaffold organizing ER-PM nanodomains that regulate inflammatory pain signaling through Ca2+-dependent interactions.

This study identifies and validates viral circular RNAs produced during Zika virus infection in neural stem cells.

The paper uses probabilistic inference in pedigreed canine populations to estimate disease-causing allele frequencies more comprehensively than genetic tests alone, showing improved monitoring of recessive diseases.

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

This study shows that COG5 deficiency disrupts Golgi organization and affects neural progenitor fate during human brain development through altered trafficking and glycosylation.

This study shows HIV-1 infection alters microglia transcriptome by upregulating microRNA-23b, which disrupts G3BP2 and stress granule assembly, promoting HIV-1 replication.

This study uses multi-omics to uncover Gardnerella genomic features linked to biofilm formation and interspecies interactions in the vaginal microbiome, identifying potential therapeutic targets for bacterial vaginosis.

This study predicts biological age and clinical biomarkers from cheek mucosa DNA methylation data, showing high accuracy for age and multiple biomarkers compared to blood-derived data.

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

This paper develops and tests dual AAV vectors for treating USH1B by reconstituting full-length MYO7A expression, showing safety and efficacy in non-human primates.

The paper assesses whether HIV-1 infection confers resistance to CTL-mediated cell death and finds no intrinsic resistance, with survival differences attributed to MHC class I downregulation.

This paper engineers probiotic bacteria to target granulomas and reduce mycobacterial infection in vitro and in vivo.

The paper provides validated 1H,15N backbone assignments for commercial hen egg white lysozyme at natural 15N abundance and demonstrates their utility in various applications.