Elena Restelli

This study shows that COG5 deficiency disrupts Golgi organization and affects neural progenitor fate during human brain development through altered trafficking and glycosylation.

AAV-mediated SIL1 gene therapy prevents cerebellar degeneration and ataxia in a mouse model of Marinesco-Sjögren syndrome by preserving Purkinje cells and reducing ER stress.

This study compares human and chimpanzee neurons to show that human neurons have altered lipid metabolism and trafficking, contributing to delayed synaptic maturation during brain development.

This paper introduces a robotic system for high-throughput single-cell manipulation in human brain organoids using vision guidance.

This study shows adducins regulate proliferation and fate of neural progenitors in mouse, ferret, and human neocortex, affecting neurogenesis.

MicroSplit uses deep learning to computationally unmix fluorescent microscopy data, enabling faster imaging and reduced photon exposure by separating multiple cellular structures from a single channel.

This study tests trazodone, dibenzoylmethane, and tauroursodeoxycholic acid in MSS mice but finds no prevention of motor dysfunction or neurodegeneration.

This study investigates the role of SUMO2/3 modification in mitigating Tau-induced synaptic and cognitive dysfunction in disease models.

This study shows that in Alzheimer's disease astrocytes, protein synthesis is impaired through PERK-independent p-eIF2 activation, linked to altered ER-mitochondria interactions, affecting homeostatic functions.