Annelies Stevaert

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

This paper identifies N-benzamides as inhibitors of influenza virus fusion, showing efficacy against H1 and H5 hemagglutinins with low EC50 values and high selectivity.

This study identifies mutations in influenza hemagglutinin that increase acid-stability and decrease cleavability, with implications for viral transmissibility and vaccine development.

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.