Author

Ahmet Buğra Tufan

Boston Children's HospitalORCID 0000-0002-8734-9736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Anje SporbertiD· 1 shared Claus ScheidereitiD· 1 shared David M. KnipeiD· 1 shared Elena Goldberg· 1 shared Hao WuiD· 1 shared Hyung Suk OhiD· 1 shared Jens Peter von KriesiD· 1 shared João A. PauloiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Anje SporbertORCID

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2 papers

Recent·Most cited

Structures of MyD88 and its oncogenic mutant reveal DNA binding with implications for cytosolic DNA sensing

Pietro Fontana, Ahmet Buğra Tufan, Patrick Günther, Elena Goldberg, Sebastian Dörfler, Setu M. Vora, Leo Schirokauer, João A. Paulo, Hyung Suk Oh, Steven P. Gygi, David M. Knipe, Hao Wu

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

bioRxiv · Oct 29, 2026 · PreprintImmunology

TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation

Ahmet Buğra Tufan, Katina Lazarow, Marina Kolesnichenko, Anje Sporbert, Jens Peter von Kries, Claus Scheidereit

This study identifies TSG101 as essential for PARylation and DNA damage-induced NF-κB activation, showing its role in DNA repair and apoptosis protection.

The EMBO Journal · Sep 20, 2022Peer-reviewedMolecular Biology