Author

Pietro Fontana

Boston Children's HospitalORCID 0000-0003-3215-3784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:imaging· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Hao WuiD· 2 shared Setu M. VoraiD· 2 shared Ahmet Buğra TufaniD· 1 shared Airlie J. McCoyiD· 1 shared Akiko IwasakiiD· 1 shared Alisia FadiniiD· 1 shared Amir R. Khan· 1 shared David M. KnipeiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

Hao WuORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 29, 2026

Structures of MyD88 and its oncogenic mutant reveal DNA binding with implications for cytosolic DNA sensing

Pietro Fontana, Ahmet Buğra Tufan, Patrick Günther…·Hao Wu

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

DOI 10.64898/2026.10.21.760499

humanprotein structure

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BiophysicsNature MethodsPeer-reviewedApr 1, 2026

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AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network

Alisia Fadini, Minhuan Li, Airlie J. McCoy…·Mohammed AlQuraishi

ROCKET refines AlphaFold2 predictions against crystallographic, cryo-EM and cryo-ET data by gradient descent on MSA cluster profiles, capturing loop flips and domain shifts without retraining.

22 citationstop 1%

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Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedFeb 11, 2022

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Targeting Stem-loop 1 of the SARS-CoV-2 5'UTR to suppress viral translation and Nsp1 evasion

Setu M. Vora, Pietro Fontana, Tianyang Mao…·Hao Wu

SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.

159 citationstop 1%

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