Discover, rate, and discuss biology papers.

This paper identifies Yra2's role in ubiquitin-mediated proteolysis of Cse4 to prevent its mislocalization and maintain chromosomal stability in budding yeast.

This study identifies three photoprotective mechanisms in diatoms under light stress: detachment of oxygen-evolving complex proteins, NPQ in the antenna, and energy spillover between photosystems.

The paper identifies de novo open reading frames in Drosophila melanogaster that show sequence signatures indicative of metal-binding potential through bis-histidine motifs.

Arena3D 3.0 is a web server for exploring, analyzing, and sharing multilayered biological networks in 3D with various layouts and visualization tools.

The paper identifies tau as an m6A-associated RNA binding protein that causes RNA dysregulation in MAPT coding-variant patients and V337M iNeurons.

The paper detects malignant hematopoietic stem cells (HSCs) in myelodysplastic neoplasms (MDS) using low-input sequencing and shows they predict relapse after transplantation.

This study examines how attentional load affects intracortical brain-computer interface (iBCI) performance during dual-tasking, finding robust performance but individual variability.

The paper identifies CYLD as a host deubiquitinase recruited to Listeria monocytogenes surface via InlC and RNF213, which facilitates cell-to-cell spread in epithelial cells.

This study investigates how termite soldiers use viscoelastic secretions to create a liquid lasso for defense, extending their reach and trapping predators.

This study decomposes gait cycles using a dynamic system framework to identify coordination patterns in human locomotion.

This study shows that the antibody 1H5 targets activated ADAM10 to suppress NOTCH-driven glioma progenitors, reducing tumor growth and improving survival in xenograft models.

The paper evaluates sparse autoencoder features on various embeddings, finding that reproducibility does not guarantee meaningfulness, and proposes reporting features with concept coverage and purity.

The paper introduces NanoPro, a nanovector therapy platform using probiotically-released tumor-binding tags to target antigenically indistinct tumors, demonstrating in vitro efficacy with high transduction rates.

This paper introduces SpaceDX, a method that jointly identifies differentially expressed genes and their spatial localization in multi-subject spatial transcriptomics data, improving detection compared to traditional approaches.

This study shows mechanical stress releases mitochondrial dsRNA, activating RIG-I to drive osteogenic differentiation and calcification in aortic disease, with JAK/STAT inhibition offering therapeutic potential.

This study shows that song learning in wild zebra finches occurs during a sensitive period that outlasts parent-offspring cohesion, suggesting broader social learning opportunities.

Spatialsnake provides a flexible workflow for spatial transcriptomics analysis across multiple platforms, enabling analysis of selected populations and tissue regions with adjustable parameters.

This study uses a PAX3::FOXO1 inducible model to show P3F initiates ARMS transformation but is not required for maintaining proliferation or transcriptional programs.

The paper identifies molecularly defined subtypes of olfactory bulb output neurons and their distinct projection patterns to cortical targets.

The paper shows that transcriptomic similarity can rank candidate sources for response prediction better than random, but does not resolve aggregation or transfer uncertainty.