Viviane S. Tabar

This study shows that the antibody 1H5 targets activated ADAM10 to suppress NOTCH-driven glioma progenitors, reducing tumor growth and improving survival in xenograft models.

This study develops a method to derive and maintain specific subtypes of human midbrain dopaminergic neurons in vitro, revealing their functional and molecular characteristics and potential vulnerability in disease.

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

The paper analyzes the evolutionary trajectories of high-level copy-number amplifications in cancer cell genomes to distinguish between extrachromosomal and intrachromosomal amplification mechanisms.

The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.

This study identifies a pathogenic subpopulation of glioma-associated macrophages (mGAMs) linked to glioma progression through GRN analysis and functional validation.

This study improves the yield and subtype identity of hPSC-derived midbrain dopamine neurons through optimized WNT and FGF18 signaling modulation, enhancing their functional and transcriptional similarity to primary neurons.

This paper introduces PERFF-seq, a method to profile rare cell states via scRNA-seq by enriching for specific RNA transcripts, demonstrating its application in immune and brain tissues.

The paper constructs a molecular atlas of the human brain vasculature using single-cell RNA sequencing, revealing molecular heterogeneity and disease-related alterations in vascular cells.