Simon Chang

Joint localization and testing reveals spatial context of differential expression

This paper introduces SpaceDX, a method that jointly identifies differentially expressed genes and their spatial localization in multi-subject spatial transcriptomics data, improving detection compared to traditional approaches.

Loss of noradrenergic Fkbp5 disrupts social behavior and norepinephrine dynamics in the basolateral amygdala

This study shows that Fkbp5 in noradrenergic neurons affects social behavior and norepinephrine dynamics in the basolateral amygdala, specifically in male mice.

Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development

This study identifies CRH-expressing OPCs that prevent premature differentiation following CNS injury and in early development, highlighting CRHR1's role in oligodendrogenesis.

Food and water uptake are regulated by distinct central amygdala circuits revealed using intersectional genetics

The paper identifies distinct central amygdala circuits regulating food and water uptake using intersectional genetics and in vivo calcium imaging.

Molecular and neural mechanisms of behavioural integration in the extended-amygdala

The paper identifies neural ensembles in the extended amygdala of mice that encode diverse behaviours across contexts and links these ensembles to gene expression profiles associated with psychiatric and neurodegenerative disorders.

Spatial Transcriptomics Using Multiplexed Deterministic Barcoding in Tissue

This study introduces xDbit, a multiplexed spatial transcriptomics method, and demonstrates its application in characterizing murine kidney tissue.

Tripartite extended amygdala - basal ganglia CRH circuit drives arousal and avoidance behaviour

The paper identifies a novel tripartite CRH circuit connecting extended amygdala and basal ganglia that drives arousal and avoidance behaviour through CRH receptor 1 in the substantia nigra.