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A hybrid 4D whole-cell simulation of the minimal bacterium JCVI-syn3A integrates spatial reaction-diffusion, metabolism, polymer chromosome dynamics, and division across a complete 105-minute cell cycle.

ODIEU pairs human odor texts for 10,124 molecules with olfaction-tuned Sentence-BERT evaluators; CIRANO, a frozen GPT-2 with a molecular prefix, generates descriptions approaching human agreement.

Oral Faecalibacterium prausnitzii, the taxon most consistently depleted in PD stool, improved motor and GI deficits and lowered α-synuclein aggregates in male Thy1-ASO mice.

Across nearly one million progeny from 10 species, species best predicts homing drive inheritance, while promoter, parent sex and maternal deposition each explain little of the inheritance variation.

Antscan provides 2,193 standardized whole-body 3D synchrotron micro-CT datasets across 792 ant species (212 genera), pairing morphological volumes with automated deep-learning segmentation and genome sequencing projects.

Reanalysis of public transcriptomes shows PDLIM2 is repressed in influenza and COVID-19, with lower blood leukocyte levels in severe disease and NF-κB/STAT3 hyperactivation in low-PDLIM2 cells.

Since its 2013 launch, bioRxiv has posted more than 310,000 life-science preprints; about 80% later reach journals, and surveyed authors rarely report negative consequences of posting.

A gut consumer-resource model with explicit metabolic pathways yields competition-dominated healthy and cooperation-dominated dysbiotic states; an interaction-balance index (ENBI) detects this shift in human disease cohorts.

Across 14 sarcoma and mimic subtypes, six pathology foundation models beat ResNet50 but lost accuracy under multi-institutional staining; adding 121 externally stained slides narrowed the gap.

Domestic cat kidneys hold more Oil Red O-stained lipid than dog kidneys, and their tubular droplets carry a less-polar band containing ether-linked lipids resembling monoalkyldiacylglycerols.

A sequencing-based neutralization assay across 78 H3N2 HA strains and 150 sera shows strain growth in 2023 tracks the fraction of sera with low titers, but not pooled-serum titers.

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

During early-2025 US honey bee collapses (>60% losses), dying bees carried high loads of infectious DWV-A, DWV-B, and ABPV, and 100% of screened Varroa mites carried the amitraz-resistance allele.

Tobacco rattle virus delivery of engineered ISDra2 variant eTnpBc and its guide RNA as a single transcript achieves up to 90% somatic and 100% heritable editing in Nicotiana benthamiana.

Endothelial Twist1 drives partial and advanced endothelial-to-mesenchymal transition via PELP1 and AEBP1-COL4A1 signaling, increasing collagen and ACTA2+ cells to stabilize atherosclerotic plaques in male mice and human carotid arteries.

In 4-month-old APOE targeted-replacement mice, APOE4 remodels the liver proteome sex-dependently; in isogenic iPSC-derived hepatocytes it impairs respiration and raises glycolysis and lipid droplets.

Dividing Cmax by lowest in vitro toxicity potency separates drugs by liver-injury (DILI) risk, AUC up to 96%; PBK-predicted Cmax without clinical data reaches 91%.

Across 269 functional responses from 45 freshwater fish species, invasive species exceed non-invasive species only when sampled in their native range; introduced populations match non-invasive species.

flatbug, a YOLOv8 instance-segmentation model with multi-scale tile-pyramid inference and polygon-based deduplication, segments terrestrial arthropods across 23 image subdatasets and transfers to held-out subdatasets with a modest F1 penalty.

AgentD, a GPT-4o agent wired to retrieval, generative, ADMET and Boltz-2 tools, chains early drug-discovery steps for BCL-2 and raised molecules with QED > 0.6 from 34 to 55.