Author

Colton R Lysaker

University of KansasORCID 0000-0002-9085-5285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Chelsea N. JohnsoniD· 2 shared Edziu FranczakiD· 2 shared Heather WilkinsiD· 2 shared Jill K. MorrisiD· 2 shared John P. ThyfaultiD· 2 shared Maggie N. Benson· 2 shared Paige C. GeigeriD· 2 shared Vivien CsikósiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

Chelsea N. JohnsonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

APOE4 drives widespread changes to the hepatic proteome and alters metabolic function

Colton R Lysaker, Chelsea N. Johnson, Vivien Csikós, Edziu Franczak, Ashley L. Tetlow, Maggie N. Benson, John P. Thyfault, Paige C. Geiger, Jill K. Morris, Heather Wilkins

In 4-month-old APOE targeted-replacement mice, APOE4 remodels the liver proteome sex-dependently; in isogenic iPSC-derived hepatocytes it impairs respiration and raises glycolysis and lipid droplets.

iScience · Feb 17, 2026Peer-reviewedPhysiology✦ In-depth digest

Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis

Colton R Lysaker, Chelsea N. Johnson, Vivien Csikós, Edziu Franczak, Maggie N. Benson, Caleb A. Gilmore, Cole J. Birky, Xin C. Davis, Colin S. McCoin, Keith P. Smith, Patrycja Puchalska, Peter A. Crawford, Chad M Slawson, John P. Thyfault, Paige C. Geiger, , Heather Wilkins

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

bioRxiv · Jun 15, 2025 · PreprintNeuroscience