Dunja Aksentijević

Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes

This study shows chronic kidney disease causes systemic metabolic failure across multiple organs, impairing cardiac function and stress resilience by depleting bioenergetic reserves.

Characterisation of distinct senescent-like T cell populations during healthy and unhealthy ageing

This study identifies a distinct senescent-like CD8 TEMRA cell population in older individuals with type 2 diabetes, linked to metabolic inflammation and impaired immune function.

Bat power-metabolic profiling of the Egyptian fruit bat Rousettus aegyptiacus reveals distinctive cardiac adaptations

This study identifies unique cardiac metabolic adaptations in Egyptian fruit bats using metabolomics and computational modeling, revealing reliance on lipid oxidation and oxidative phosphorylation.