Discover, rate, and discuss biology preprints.

PPI-Rescue restores eye development by reconstituting transcription complexes in Drosophila using targeted mutations and cofactor interactions.

This paper evaluates how site heterogeneity affects brain-phenotype predictions in multi-site data, finding that larger sample sizes improve accuracy more than multi-site composition.

GOTSurv models patient-specific disease progression from cross-sectional survival data, identifying heterogeneous risk strata and individualized progression trajectories without predefined risk cut-offs.

This study shows thalamic stereo-EEG can detect sleep stages N2 and N3 with high accuracy, comparable to scalp EEG, using machine learning classifiers.

This study functionally characterizes Kv7.5 channel variants, identifying gain- and loss-of-function effects and proposing a z-score classification for pathogenicity.

The paper analyzes the lipidome of compact myelin from young, middle-aged, and aged mice to identify age-related compositional changes associated with white matter degeneration.

This study shows that late radiation-induced brain injury in mice causes functional cerebrovascular impairment without structural vessel loss, highlighting endothelial dysfunction as a key factor.

This study examines parallel evolution of nuclear OXPHOS genes in threespine stickleback across freshwater populations and identifies mitonuclear evolutionary coupling in specific functional modules.

This study shows that inhibiting MCT1 and MCT4 with acriflavine neutralizes tumor acidosis, restores chemotherapy efficacy, and is monitored by 3T CEST MRI without using bicarbonate.

This study identifies OlsF-dependent ornithine lipid biosynthesis as a phosphate-responsive pathway that remodels the outer membrane and enhances polymyxin tolerance in Enterobacterales.

The paper analyzes exon usage and alternative splicing in heat-evolved strains of the coral symbiont Cladocopium proliferum to identify genetic differences associated with increased thermal tolerance.

Peptorama provides tools for creating and analyzing non-ribosomal peptide structures, enabling efficient comparison of known and predicted peptides to aid in biodiscovery.

This paper identifies a covalent inhibitor of SOS1-KRAS binding by screening fragments that form bonds at Tyr-884, showing time- and concentration-dependent inhibition of KRAS nucleotide exchange.

This study identifies chromothripsis as a common driver of pleural mesothelioma, linked to gene deletions and poor patient survival.

The paper introduces PRISM-Lys, a chemoproteomic method to quantitatively map lysine redox states, revealing site-specific changes during ferroptosis.

This study identifies a distinct circulating extracellular vesicle signature in bicuspid aortic valve disease through single-vesicle analysis and proteomic profiling.

The paper analyzes drug response direction across glioma states using single-cell RNA-seq data, finding that response direction is consistent across states but magnitude varies.

The paper introduces SMOOTHY-FISH, a method to visualize short RNA motifs at single-molecule resolution, revealing new spatial RNA biology insights in single cells and mouse brain tissues.

This paper presents a chromosome-level genome assembly for the wolverine, providing a more complete and sex chromosome-inclusive reference for conservation studies.

The paper presents GAIA, a global atlas of immune alleles, showing that underrepresented groups have more diverse alleles needed for vaccine design than Northwest European groups.