Author

Zhipeng A. Wang

Brigham and Women's HospitalORCID 0000-0002-5693-7359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Eunju NamiD· 2 shared Kwangwoon LeeiD· 2 shared Ling ZhangiD· 2 shared Nima SharifiiD· 2 shared Philip A. ColeiD· 2 shared Xin A. WANGiD· 2 shared Yuan-Fei ZhouiD· 2 shared Adelina AndreiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Eunju NamORCID

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4 papers

Recent·Most cited

Paired-probe chemoproteomic strategy enables global site-resolved quantification of lysine redox states

Yuan-Fei Zhou, Ling Zhang, D. M. Nirosh Udayanga, Xin A. WANG, Hasim Bakbak, Hemendra N. Shah, Nima Sharifi, Zhipeng A. Wang

The paper introduces PRISM-Lys, a chemoproteomic method to quantitatively map lysine redox states, revealing site-specific changes during ferroptosis.

bioRxiv · Nov 4, 2026 · PreprintBiochemistry

Ketone Bodies-mediated Cysteine Modifications Discovered by Chemical Proteomics

Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang

This study identifies ketone body-mediated cysteine modifications using chemical proteomics, revealing new enzymatic pathways and modifications beyond lysine acylations.

bioRxiv · May 25, 2025 · PreprintBiochemistry

Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas J. Chen, Khanh Hung Nguyen, Hanjie Jiang, Zhipeng A. Wang, Kwangwoon Lee, , Ning Zheng

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

Nature · Feb 12, 2025Peer-reviewedMolecular Biology

A circular engineered sortase for interrogating histone H3 in chromatin

Samuel D. Whedon, Kwangwoon Lee, Zhipeng A. Wang, Emily Zahn, Congcong Lu, Maheeshi Yapa Abeywardana, Louise Fairall, Eunju Nam, Sarah E. DuBois-Coyne, Pablo De Ioannes, Xinlei Sheng, Adelina Andrei, Emily Lundberg, Jennifer Jiang, Karim‐Jean Armache, , Philip A. Cole

This paper introduces an engineered sortase, cW11, for modifying and isolating histone H3 tails to study epigenetic modifications and their effects on enzyme processing and protein recognition.

Journal of the American Chemical Society · Nov 25, 2024Peer-reviewedBiochemistry