Joseph M. Boll

This study identifies OlsF-dependent ornithine lipid biosynthesis as a phosphate-responsive pathway that remodels the outer membrane and enhances polymyxin tolerance in Enterobacterales.

This study identifies the functional interplay between PBP1A and LdtJ in Acinetobacter baumannii, showing that disrupting their coordination weakens the cell envelope and increases colistin resistance.

This study identifies disruption of the DNA repair protein RuvB as a mechanism promoting minocycline resistance in Acinetobacter baumannii through enhanced biofilm formation and extracellular DNA accumulation.

The paper shows that disrupting phospholipid homeostasis in Gram-negative bacteria enables LOS-deficient, colistin-resistant variants by altering outer membrane structure and peptidoglycan synthesis.

This study shows that the Tol-Pal system in Acinetobacter baumannii is conditionally required for envelope organization under specific environmental stresses but not under standard lab conditions.

This study investigates the distinct roles of DD-peptidases in Acinetobacter baumannii, showing their unique contributions to cell morphology, growth, and peptidoglycan composition, with implications for antimicrobial therapy.

The paper identifies a clinically silent resistance phenotype in Acinetobacter baumannii that allows survival during colistin therapy despite standard susceptibility testing.

This study investigates the role of LdtJ in Acinetobacter baumannii, showing its impact on peptidoglycan integrity and outer membrane lipid asymmetry, with defects suppressed by disrupting the Mla pathway.

This study shows that phosphate limitation in Gram-negative ESKAPE pathogens triggers alternative lipid synthesis, enabling antibiotic tolerance through reduced interaction with cationic antimicrobial peptides.

This paper identifies a PmrAB-independent mechanism of colistin heteroresistance in Enterobacter cloacae involving PhoPQEcl-mediated addition of 4-amino-4-deoxy-l-arabinose to lipid A.