Fangyuan Ding

The paper introduces SMOOTHY-FISH, a method to visualize short RNA motifs at single-molecule resolution, revealing new spatial RNA biology insights in single cells and mouse brain tissues.

The paper identifies a nuclear RNA degradation code (NRDC) that recognizes transcripts with both a 5' splice site and a poly(A) junction, leading to their degradation and contributing to disease.

This study investigates the dynamics and functional roles of negative autoregulation by the SF2 splicing factor in single cells, showing its role in regulating protein concentration and reducing cell-to-cell variability.

The paper introduces a method to measure splicing efficiency at single-cell level and finds it increases with gene expression levels, suggesting an economy of scale effect.