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InSpace quantifies subcellular organization by preserving localization and molecular co-occurrence, revealing spatial programs in B and plasma cells across cancers.

This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.

This study identifies convergent genomic and gene-level constraints in grasses adapting to extreme environments using phylogenomic data and large language models.

ToxINsight provides a web platform for analyzing snake venom toxin sequences, structures, ligand interactions, and geographical distributions to aid in antivenom development.

The paper identifies polar domains in Arabidopsis male and female gametophytes using conserved proteins, revealing a universal polarity system and uncovering novel polar domains.

This study examines age-related changes in the canine oral microbiome, finding increased anaerobic taxa and amino acid degradation potential with age.

This study shows that CBD reduces glucagon secretion in mouse αTC1-6 cells by altering lysosomal trafficking and secretion pathways.

This study identifies regulatory interactions between sRNAs and transcription factors in S. aureus, showing their roles in stress responses and virulence.

This study shows that exercise timing does not affect overall daily glucose exposure but alters acute glucose dynamics and variability.

This study determines the structure of influenza D virus NS1, identifies a novel Zn-binding site and RNA-binding activity in its CTD, and shows their importance for viral replication.

This study shows that NAD metabolism supports CTCF-cohesin chromatin regulation in EBV-transformed B-cells and identifies NAMPT inhibition as a potential therapeutic strategy.

This study identifies the structural basis of sTREM2-TG2 interaction in Alzheimer's disease and develops improved peptide modulators based on these findings.

This study generates an isogenic iPSC panel to investigate ATN1's role in human development and disease, revealing proliferation deficits and toxic gain-of-function effects in mutant ATN1 lines.

This study shows that nucleus accumbens acetylcholine dips track reward value and delay, influencing adaptive choice in mice during delay discounting tasks.

This study shows JAK1/2 inhibition reduces pathogenic immune responses and restores tissue integrity in chronic skin inflammation by shifting immunity toward IL-17 responses.

This study identifies divergent brain pathology in preterm infants with NEC, showing distinct cellular and molecular changes in the pons and cerebellum.

This study characterizes the MERS-CoV replication-transcription complex and shows its structural similarity to SARS-CoV-2, with cross-species compatibility highlighting evolutionary conservation and virus-specific adaptations.

This study designs and validates protease-resistant antiviral peptides that inhibit SARS-CoV-2 fusion, showing improved efficacy in vitro and in vivo.

This study identifies mosaic chromosomal alterations in healthy human tissues, revealing tissue-specific patterns of mitotic errors and purifying selection across aging.

This study identifies TREM2's role in atherosclerosis regression by enhancing efferocytosis in lipid-experienced macrophages, suggesting TREM2 as a therapeutic target for plaque stabilization.