Failed remyelination of the non-human primate optic nerve leads to axon degeneration, retinal damages and visual dysfunction.
Nadège Sarrazin, Estelle Chavret-Reculon, Corinne Bachelin, Mehdi Felfli, Rafik Arab, Sophie Gilardeau, Elena Brazhnikova, Élisabeth Dubus, Lydia Yahia‐Cherif, Jean Lorenceau, Serge A. Picaud, Serge Georges Rosolen, Pierre Moissonnier, Pierre Pouget, Anne Baron‐Van Evercooren
This paper presents a non-human primate model of optic nerve demyelination that recapitulates key features of MS lesions, showing failed remyelination, axonal degeneration, and visual dysfunction.
Proceedings of the National Academy of Sciences · Mar 2, 2022Peer-reviewedNeuroscience